UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C.  20549

                                    FORM 13F

                              FORM 13F COVER PAGE


                 Report for the Quarter Ended September 30, 2010



                          AMERICAN FINANCIAL GROUP, INC.
                 One East Fourth Street, Cincinnati, Ohio 45202
     -------------------------------------------------------------------------
     (Name and Address of Institutional Investment Manager Filing this Report)


                         Form 13F File Number:  28-4389


The institutional investment manager filing this report and the person by whom
it is signed hereby represent that the person signing the report is authorized
to submit it, that all information contained herein is true, correct and
complete, and that it is understood that all required items, statements,
schedules, lists, and tables, are considered integral parts of this form.

                                 Robert H. Ruffing
                     	   Vice President and Controller
                                   (513) 579-2144
                -----------------------------------------------
                (Name, Title and Phone Number of Person Signing
                 this Report on Behalf of Reporting Manager)



Signature:

/s/Robert H. Ruffing                  Cincinnati, Ohio         November 11, 2010
- -------------------------------
Robert H. Ruffing
Vice President and Controller


Report Type:
     [X]  13F HOLDINGS REPORT.
     [ ]  13F NOTICE.
     [ ]  13F COMBINATION REPORT.










FORM 13F SUMMARY PAGE --------------------- Number of Other Included Managers: 1 ----------- Form 13F Information Table Entry Total: 72 ----------- Form 13F Information Table Value Total (thousands): $481,605 ----------- Name and 13F file numbers of all Institutional Investment Managers with respect to which this schedule is filed (other than American Financial Group, Inc.): Number 13F File Number Name of Subsidiary ------ --------------- ------------------------------------ 1. 28-498 Great American Insurance Company

FORM 13F INFORMATION TABLE Column 4: Column 5: Column 8: Column 2: Market Shares or Column 6: Column 7: Voting Authority Column 1: Title of Column 3: Value Principal Investment Other --------------------------- Name of Issuer Class CUSIP (000's) Amount Discretion Managers Sole Shared None -------------- ---------------- ----------- --------- ------------ ---------- -------- ---------- ------ --------- HOLDINGS OF GREAT AMERICAN INSURANCE COMPANY - -------------------------------------------- AMERICAN COMMERCIAL LINES COM PAR $0.01 025195 40 5 1,959 70,250SH Defined 1 70,250 AMERICAN RAILCAR INDS INC COM 02916P 10 3 1,066 68,000SH Defined " 68,000 ANWORTH MORTGAGE ASSET CP COM 037347 10 1 891 125,000SH Defined " 125,000 BANK OF AMERICA CORPORATION COM 060505 10 4 1,417 108,120SH Defined " 108,120 CALAMP CORP COM 128126 10 9 359 139,750SH Defined " 139,750 CHEVRON CORP NEW COM 166764 10 0 10,034 123,800SH Defined " 123,800 COCA COLA CO COM 191216 10 0 9,919 169,500SH Defined " 169,500 COMCAST CORPORATION NEW CL A 20030N 10 1 7,051 390,000SH Defined " 390,000 DELTA AIR LINES INC DEL COM NEW 247361 70 2 154 13,239SH Defined " 13,239 DISH NETWORK CORP CL A 25470M 10 9 724 37,675SH Defined " 37,675 ECHOSTAR CORP CL A 278768 10 6 473 24,786SH Defined " 24,786 FLAGSTAR BANCORP INC COM NEW 337930 50 7 30 16,500SH Defined " 16,500 FULL HOUSE RESORTS INC COM 359678 10 9 111 35,331SH Defined " 35,331 HEINZ H J CO COM 423074 10 3 9,557 201,750SH Defined " 201,750 INSTEEL INDUSTRIES INC COM 45774W 10 8 221 24,609SH Defined " 24,609 INTEL CORP COM 458140 10 0 9,456 492,500SH Defined " 492,500 INTERNATIONAL BUSINESS MACHS COM 459200 10 1 10,027 74,750SH Defined " 74,750 JOHNSON & JOHNSON COM 478160 10 4 9,728 157,000SH Defined " 157,000 KELLOGG CO COM 487836 10 8 9,438 186,850SH Defined " 186,850 KIMBERLY CLARK CORP COM 494368 10 3 9,530 146,500SH Defined " 146,500 KRAFT FOODS INC CL A 50075N 10 4 9,574 310,250SH Defined " 310,250 LOCKHEED MARTIN CORP COM 539830 10 9 1,622 22,750SH Defined " 22,750 MYR GROUP INC DEL COM 55405W 10 4 6,304 384,615SH Defined " 384,615 MCDONALDS CORP COM 580135 10 1 9,649 129,500SH Defined " 129,500 MERCK & CO INC NEW COM 58933Y 10 5 8,982 244,000SH Defined " 244,000 MICROSOFT CORP COM 594918 10 4 9,539 389,500SH Defined " 389,500 MOTRICITY INC COM 620107 10 2 991 82,525SH Defined " 82,525 NATIONAL INTERSTATE CORP COM 63654U 10 0 222,054 10,200,000SH Defined " 10,200,000 O CHARLEYS INC COM 670823 10 3 212 29,500SH Defined " 29,500 OMEROS CORP COM 682143 10 2 744 102,040SH Defined " 102,040 PATTERSON UTI ENERGY INC COM 703481 10 1 683 40,000SH Defined " 40,000 PEPSICO INC COM 713448 10 8 9,637 145,050SH Defined " 145,050 PFIZER INC COM 717081 10 3 4,979 290,000SH Defined " 290,000 RAYTHEON CO COM NEW 755111 50 7 1,577 34,500SH Defined " 34,500 3M CO COM 88579Y 10 1 9,928 114,500SH Defined " 114,500 TIME WARNER INC COM NEW 887317 30 3 267 8,716SH Defined " 8,716 TORTOISE ENERGY CAP CORP COM 89147U 10 0 667 25,800SH Defined " 25,800 VIRGIN MEDIA INC COM 92769L 10 1 17,014 737,807SH Defined " 737,807 WALGREEN CO COM 931422 10 9 8,258 246,500SH Defined " 246,500

HOLDINGS OF OTHER ENTITIES EACH HAVING LESS THAN $100 MILLION IN 13F SECURITIES - ------------------------------ ACE LTD SHS H0023R 10 5 3,670 63,000SH Sole 63,000 AMERICAN COMMERCIAL LINES COM PAR $0.01 025195 40 5 2,377 85,250SH Defined 85,250 AMERICAN RAILCAR INDS INC COM 02916P 10 3 1,060 67,581SH Defined 67,581 ANWORTH MORTGAGE ASSET CP COM 037347 10 1 891 125,000SH Defined 125,000 BANK OF AMERICA CORPORATION COM 060505 10 4 4,239 323,480SH Defined 323,480 BERKLEY W R CORP COM 084423 10 2 3,167 117,000SH Sole 117,000 CALAMP CORP COM 128126 10 9 362 140,750SH Defined 140,750 CHUBB CORP COM 171232 10 1 4,046 71,000SH Sole 71,000 DELTA AIR LINES INC DEL COM NEW 247361 70 2 176 15,097SH Defined 15,097 DEX ONE CORP COM 25212W 10 0 132 10,772SH Defined 10,772 DISH NETWORK CORP CL A 25470M 10 9 1,086 56,512SH Defined 56,512 EATON VANCE TAX MNG GBL DV E COM 27829F 10 8 438 40,000SH Defined 1 40,000 ECHOSTAR CORP CL A 278768 10 6 709 37,179SH Defined 37,179 FLAGSTAR BANCORP INC COM NEW 337930 50 7 30 16,500SH Defined 16,500 FULL HOUSE RESORTS INC COM 359678 10 9 99 31,617SH Defined 31,617 INSTEEL INDUSTRIES INC COM 45774W 10 8 200 22,216SH Defined 22,216 ISHARES TR MSCI EAFE IDX 464287 46 5 2,362 43,000SH Defined 1 43,000 ISHARES TR DJ US TELECOMM 464287 71 3 208 9,550SH Defined " 9,550 KEYCORP NEW COM 493267 10 8 416 52,222SH Defined " 52,222 MANAGED HIGH YIELD PLUS FD I COM 561911 10 8 23 10,000SH Defined " 10,000 MERCK & CO INC NEW COM 58933Y 10 5 736 20,000SH Defined 20,000 MOTRICITY INC COM 620107 10 2 1,487 123,787SH Defined 123,787 O CHARLEYS INC COM 670823 10 3 321 44,654SH Defined 44,654 OMEROS CORP COM 682143 10 2 1,116 153,061SH Defined 153,061 PATTERSON UTI ENERGY INC COM 703481 10 1 683 40,000SH Defined 40,000 PFIZER INC COM 717081 10 3 343 20,000SH Defined 20,000 POWERSHARES ETF TRUST DYNAMIC MKT PT 73935X 10 4 960 24,400SH Defined 1 24,400 POWERSHARES ETF TRUST HI YLD EQ DVDN 73935X 30 2 178 21,300SH Defined " 21,300 SPDR S&P 500 ETF TR TR UNIT 78462F 10 3 5,022 44,000SH Defined " 44,000 SELECT SECTOR SPDR TR SBI CONS STPLS 81369Y 30 8 977 35,060SH Defined " 35,060 SELECT SECTOR SPDR TR SBI INT-UTILS 81369Y 88 6 235 7,500SH Defined " 7,500 TORTOISE ENERGY CAP CORP COM 89147U 10 0 2,221 85,900SH Defined 85,900 VIRGIN MEDIA INC COM 92769L 10 1 26,809 1,162,588SH Defined 1,162,588 ---------- REPORT TOTAL $481,605 ==========